The effect of Nipped-B-like (Nipbl) haploinsufficiency on genome-wide cohesin binding and target gene expression: modeling Cornelia de Lange syndrome

The effect of Nipped-B-like (Nipbl) haploinsufficiency on genome-wide cohesin binding and target gene expression: modeling Cornelia de Lange syndrome

Abstract Background Cornelia de Lange syndrome (CdLS) is a multisystem developmental disorder frequently associated with heterozygous loss-of-function mutations of Nipped-B-like (NIPBL), the human homolog of Drosophila Nipped-B. NIPBL loads cohesin onto chromatin. Cohesin mediates sister chromatid c...

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Bibliographic Details
Main Authors: Daniel A. Newkirk, Yen-Yun Chen, Richard Chien, Weihua Zeng, Jacob Biesinger, Ebony Flowers, Shimako Kawauchi, Rosaysela Santos, Anne L. Calof, Arthur D. Lander, Xiaohui Xie, Kyoko Yokomori
Format: Article
Language:English
Published: BMC 2017-08-01
Series:Clinical Epigenetics
Subjects:
CdLS
Cohesin
Nipbl
Haploinsufficiency
Chromatin immunoprecipitation (ChIP)
Gene regulation
Online Access:http://link.springer.com/article/10.1186/s13148-017-0391-x

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http://link.springer.com/article/10.1186/s13148-017-0391-x

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