Normalizing HDAC2 Levels in the Spinal Cord Alleviates Thermal and Mechanical Hyperalgesia After Peripheral Nerve Injury and Promotes GAD65 and KCC2 Expression

Normalizing HDAC2 Levels in the Spinal Cord Alleviates Thermal and Mechanical Hyperalgesia After Peripheral Nerve Injury and Promotes GAD65 and KCC2 Expression

Neuropathic pain is a worldwide health concern with poor treatment outcomes. Accumulating evidence suggests that histone hypoacetylation is involved in development and maintenance of neuropathic pain. Thus, many natural and synthetic histone deacetylase (HDACs) inhibitors were tested and exhibited a...

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Bibliographic Details
Main Authors: Bihan Ouyang, Dan Chen, Xinran Hou, Tongxuan Wang, Jian Wang, Wangyuan Zou, Zongbin Song, Changsheng Huang, Qulian Guo, Yingqi Weng
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-04-01
Series:Frontiers in Neuroscience
Subjects:
histone deacetylase 2
neuropathic pain
spinal cord
GAD65
KCC2
Online Access:https://www.frontiersin.org/article/10.3389/fnins.2019.00346/full

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https://www.frontiersin.org/article/10.3389/fnins.2019.00346/full

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