Increase in DNA Damage by MYCN Knockdown Through Regulating Nucleosome Organization and Chromatin State in Neuroblastoma

Increase in DNA Damage by MYCN Knockdown Through Regulating Nucleosome Organization and Chromatin State in Neuroblastoma

As a transcription factor, MYCN regulates myriad target genes including the histone chaperone FACT. Moreover, FACT and MYCN expression form a forward feedback loop in neuroblastoma. It is unclear whether MYCN is involved in chromatin remodeling in neuroblastoma through regulation of its target genes...

Full description

Bibliographic Details
Main Authors: Xinjie Hu, Weisheng Zheng, Qianshu Zhu, Liang Gu, Yanhua Du, Zhe Han, Xiaobai Zhang, Daniel R. Carter, Belamy B. Cheung, Andong Qiu, Cizhong Jiang
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-07-01
Series:Frontiers in Genetics
Subjects:
neuroblastoma
MYCN
nucleosome
histone modification
DNA repair
Online Access:https://www.frontiersin.org/article/10.3389/fgene.2019.00684/full

Internet

https://www.frontiersin.org/article/10.3389/fgene.2019.00684/full

Similar Items