Evidence for a pathogenic role of different mutations at codon 188 of PRNP.

Evidence for a pathogenic role of different mutations at codon 188 of PRNP.

Clinical and pathological changes in familial Creutzfeldt-Jakob disease (CJD) cases may be similar or indistinguishable from sporadic CJD. Therefore determination of novel mutations in PRNP remains of major importance. We identified two different rare mutations in codon 188 of the prion protein gene...

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Bibliographic Details
Main Authors: Sigrun Roeber, Eva-Maria Grasbon-Frodl, Otto Windl, Bjarne Krebs, Wei Xiang, Caren Vollmert, Thomas Illig, Andreas Schröter, Thomas Arzberger, Petra Weber, Inga Zerr, Hans A Kretzschmar
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2008-05-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2366066?pdf=render

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http://europepmc.org/articles/PMC2366066?pdf=render

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