Oncogenic Gain of Function in Glioblastoma Is Linked to Mutant p53 Amyloid Oligomers

Oncogenic Gain of Function in Glioblastoma Is Linked to Mutant p53 Amyloid Oligomers

Summary: Tumor-associated p53 mutations endow cells with malignant phenotypes, including chemoresistance. Amyloid-like oligomers of mutant p53 transform this tumor suppressor into an oncogene. However, the composition and distribution of mutant p53 oligomers are unknown and the mechanism involved in...

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Bibliographic Details
Main Authors: Murilo M. Pedrote, Michelle F. Motta, Giulia D.S. Ferretti, Douglas R. Norberto, Tania C.L.S. Spohr, Flavia R.S. Lima, Enrico Gratton, Jerson L. Silva, Guilherme A.P. de Oliveira
Format: Article
Language:English
Published: Elsevier 2020-02-01
Series:iScience
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004220300031

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http://www.sciencedirect.com/science/article/pii/S2589004220300031

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