Fusobacterium nucleatum CbpF Mediates Inhibition of T Cell Function Through CEACAM1 Activation

Fusobacterium nucleatum CbpF Mediates Inhibition of T Cell Function Through CEACAM1 Activation

F. nucleatum is an anaerobic bacterium that is associated with several tumor entities and promotes tumorigenesis. Recent evidence suggests that F. nucleatum binds the inhibitory receptor carcinoembryonic antigen cell adhesion molecule 1 (CEACAM1) via the trimeric autotransporter adhesin CbpF. Howeve...

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Bibliographic Details
Main Authors: Johanna Galaski, Amjad Shhadeh, Ariana Umaña, Christopher C. Yoo, Ludovica Arpinati, Batya Isaacson, Orit Berhani, Bernhard B. Singer, Daniel J. Slade, Gilad Bachrach, Ofer Mandelboim
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-07-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
F. nucleatum
CbpF
trimeric autotransporter adhesins
CEACAM1
CEA
Online Access:https://www.frontiersin.org/articles/10.3389/fcimb.2021.692544/full

Internet

https://www.frontiersin.org/articles/10.3389/fcimb.2021.692544/full

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