PHF8 upregulation contributes to autophagic degradation of E-cadherin, epithelial-mesenchymal transition and metastasis in hepatocellular carcinoma

PHF8 upregulation contributes to autophagic degradation of E-cadherin, epithelial-mesenchymal transition and metastasis in hepatocellular carcinoma

Abstract Background Plant homeodomain finger protein 8 (PHF8) serves an activator of epithelial-mesenchymal transition (EMT) and is implicated in various tumors. However, little is known about PHF8 roles in hepatocellular carcinoma (HCC) and regulating E-cadherin expression. Methods PHF8 expression...

Full description

Bibliographic Details
Main Authors: Wuhua Zhou, Li Gong, Qinchuan Wu, Chunyang Xing, Bajin Wei, Tianchi Chen, Yuan Zhou, Shengyong Yin, Bin Jiang, Haiyang Xie, Lin Zhou, Shusen Zheng
Format: Article
Language:English
Published: BMC 2018-09-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Plant homeodomain finger protein 8, PHF8
Epithelial-mesenchymal transition, EMT
Autophagy
Metastasis
Hepatocellular carcinoma, HCC
Online Access:http://link.springer.com/article/10.1186/s13046-018-0890-4

Internet

http://link.springer.com/article/10.1186/s13046-018-0890-4

Similar Items