Peroxisome Proliferator-Activated Receptors (PPAR)γ Agonists as Master Modulators of Tumor Tissue

Peroxisome Proliferator-Activated Receptors (PPAR)γ Agonists as Master Modulators of Tumor Tissue

In most clinical trials, thiazolidinediones do not show any relevant anti-cancer activity when used as mono-therapy. Clinical inefficacy contrasts ambiguous pre-clinical data either favoring anti-tumor activity or tumor promotion. However, if thiazolidinediones are combined with additional regulator...

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Bibliographic Details
Main Authors: Daniel Heudobler, Michael Rechenmacher, Florian Lüke, Martin Vogelhuber, Tobias Pukrop, Wolfgang Herr, Lina Ghibelli, Christopher Gerner, Albrecht Reichle
Format: Article
Language:English
Published: MDPI AG 2018-11-01
Series:International Journal of Molecular Sciences
Subjects:
anakoinosis
communicative reprogramming
nuclear transcription factors
metronomic low-dose chemotherapy
glitazones
all-trans retinoic acid
COX-2 inhibitor
master modulators
undruggable targets
therapy pillar
peroxisome proliferator-activated receptors (PPARs)
energy homeostasis
metabolic regulations
organ cross-talk
cancer and reprogramming of energy metabolism
systems biology
Online Access:https://www.mdpi.com/1422-0067/19/11/3540

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https://www.mdpi.com/1422-0067/19/11/3540

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