Ifenprodil and Flavopiridol Identified by Genomewide RNA Interference Screening as Effective Drugs To Ameliorate Murine Acute Lung Injury after Influenza A H5N1 Virus Infection

Ifenprodil and Flavopiridol Identified by Genomewide RNA Interference Screening as Effective Drugs To Ameliorate Murine Acute Lung Injury after Influenza A H5N1 Virus Infection

Drug repurposing is a quick and economical strategy for developing new therapies with approved drugs. H5N1 is a highly pathogenic avian influenza virus subtype that can cause severe acute lung injury (ALI) and a high mortality rate due to limited treatments. The use of RNA interference (RNAi) is a r...

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Bibliographic Details
Main Authors: Cong Zhang, Yuqing Zhang, Yuhao Qin, Qingchao Zhang, Qiang Liu, Daozhen Shang, Huijun Lu, Xiao Li, Congzhao Zhou, Fengming Huang, Ningyi Jin, Chengyu Jiang
Format: Article
Language:English
Published: American Society for Microbiology 2019-12-01
Series:mSystems
Subjects:
h5n1
lung injury
ifenprodil
flavopiridol
drug repurposing
genomewide rnai
Online Access:https://doi.org/10.1128/mSystems.00431-19

Internet

https://doi.org/10.1128/mSystems.00431-19

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