Vitamin E δ-tocotrienol induces p27(Kip1)-dependent cell-cycle arrest in pancreatic cancer cells via an E2F-1-dependent mechanism.

Vitamin E δ-tocotrienol induces p27(Kip1)-dependent cell-cycle arrest in pancreatic cancer cells via an E2F-1-dependent mechanism.

Vitamin E δ-tocotrienol has been shown to have antitumor activity, but the precise molecular mechanism by which it inhibits the proliferation of cancer cells remains unclear. Here, we demonstrated that δ-tocotrienol exerted significant cell growth inhibition pancreatic ductal cancer (PDCA) cells wit...

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Bibliographic Details
Main Authors: Pamela J Hodul, Yanbin Dong, Kazim Husain, Jose M Pimiento, Jiandong Chen, Anying Zhang, Rony Francois, Warren J Pledger, Domenico Coppola, Said M Sebti, Dung-Tsa Chen, Mokenge P Malafa
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3564846?pdf=render

Internet

http://europepmc.org/articles/PMC3564846?pdf=render

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