Identification of amino acids involved in histamine potentiation of GABA(A) receptors

Identification of amino acids involved in histamine potentiation of GABA(A) receptors

Histamine is a neurotransmitter involved in a number of physiological and neuronal functions. In mammals, such as humans and rodents, the histaminergic neurons found in the tuberomamillary nucleus (TMN) project widely throughout the central nervous system (CNS). Histamine acts as positive modulator...

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Bibliographic Details
Main Authors: Ulrike eThiel, Sarah J Platt, Steffen eWolf, Hanns eHatt, Günter eGisselmann
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-05-01
Series:Frontiers in Pharmacology
Subjects:
Histamine
modulation
GABAAR
Site-directed mutagenesis
potentiation
salt-bridge
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphar.2015.00106/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fphar.2015.00106/full

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