Nondestructive Identification of Rare Trophoblastic Cells by Endoplasmic Reticulum Staining for Noninvasive Prenatal Testing of Monogenic Diseases

Nondestructive Identification of Rare Trophoblastic Cells by Endoplasmic Reticulum Staining for Noninvasive Prenatal Testing of Monogenic Diseases

Abstract Noninvasive prenatal detection of monogenic diseases based on cell‐free DNA is hampered by challenges in obtaining a sufficient fraction and adequate quality of fetal DNA. Analyzing rare trophoblastic cells from Papanicolaou smears carrying the entire fetal genome provides an alternative me...

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Bibliographic Details
Main Authors: Yifang Huang, Bo Situ, Liping Huang, Yingsi Cao, Hong Sui, Xinyi Ye, Xiujuan Jiang, Aifen Liang, Maliang Tao, Shihua Luo, Ye Zhang, Mei Zhong, Lei Zheng
Format: Article
Language:English
Published: Wiley 2020-04-01
Series:Advanced Science
Subjects:
monogenic diseases
nondestructive identification
noninvasive prenatal testing
single‐cell isolation
trophoblastic cells
Online Access:https://doi.org/10.1002/advs.201903354

Internet

https://doi.org/10.1002/advs.201903354

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