Application of 9.4T MRI in Wilson Disease Model TX Mice With Quantitative Susceptibility Mapping to Assess Copper Distribution

Application of 9.4T MRI in Wilson Disease Model TX Mice With Quantitative Susceptibility Mapping to Assess Copper Distribution

In the current study, we used 9.4-tesla magnetic resonance imaging (9.4T MRI) and inductively coupled plasma mass spectrometry (ICP-MS) to investigate the distribution of copper in the brain samples of a murine model of Wilson’s disease (WD) following penicillamine (PCA) treatment. We also evaluated...

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Bibliographic Details
Main Authors: Yongsheng Han, Jianjian Dong, Chenchen Xu, Rao Rao, Shan Shu, Guangda Li, Nan Cheng, Yun Wu, Hongyi Yang, Yongzhu Han, Kai Zhong
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-04-01
Series:Frontiers in Behavioral Neuroscience
Subjects:
9.4-Tesla magnetic resonance
penicillamine
quantitative susceptibility mapping
TX mouse
Wilson disease
Online Access:https://www.frontiersin.org/article/10.3389/fnbeh.2020.00059/full

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https://www.frontiersin.org/article/10.3389/fnbeh.2020.00059/full

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