A theoretical insight in interactions of some chemical compounds as mTOR inhibitors

A theoretical insight in interactions of some chemical compounds as mTOR inhibitors

Abstract Background A series of known Food and Drug Administration (FDA) approved anticancer drugs were collected from the literature and docked against mTOR receptor which has been identified in present time as a target for therapeutic anticancer agents. The compounds binding affinity were calculat...

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Bibliographic Details
Main Authors: David Ebuka Arthur, Jibrin Noah Akoji, Riadh Sahnoun, Greatman C. Okafor, Karimatu Lami Abdullahi, Samira A. Abdullahi, Charles Mgbemena
Format: Article
Language:English
Published: SpringerOpen 2021-03-01
Series:Bulletin of the National Research Centre
Subjects:
SBDD
Molecular docking
Binding energy
Hydrophobic interaction
Hydrogen interaction
Drug
Online Access:https://doi.org/10.1186/s42269-021-00525-x

Internet

https://doi.org/10.1186/s42269-021-00525-x

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