Synthesis of Marine α-Methoxylated Fatty Acid Analogs that Effectively Inhibit the Topoisomerase IB from Leishmania donovani with a Mechanism Different from that of Camptothecin

Synthesis of Marine α-Methoxylated Fatty Acid Analogs that Effectively Inhibit the Topoisomerase IB from Leishmania donovani with a Mechanism Different from that of Camptothecin

Sponges biosynthesize α-methoxylated fatty acids with unusual biophysical and biological properties and in some cases they display enhanced anticancer activities. However, the antiprotozoal properties of the α-methoxylated fatty acids have been less studied. In this work, we describe the total synth...

Full description

Bibliographic Details
Main Authors: Rosa M. Reguera, Christopher F. Prada, Raquel Alvarez-Velilla, Nashbly Montano, Néstor M. Carballeira, Rafael Balaña-Fouce
Format: Article
Language:English
Published: MDPI AG 2013-09-01
Series:Marine Drugs
Subjects:
methoxylated fatty acids
leishmania donovani
2-methoxy-5,9-eicosadienoic acid
topoisomerase IB
Online Access:http://www.mdpi.com/1660-3397/11/10/3661

Internet

http://www.mdpi.com/1660-3397/11/10/3661

Similar Items