Osteopenia due to enhanced cathepsin K release by BK channel ablation in osteoclasts.

Osteopenia due to enhanced cathepsin K release by BK channel ablation in osteoclasts.

BACKGROUND: The process of bone resorption by osteoclasts is regulated by Cathepsin K, the lysosomal collagenase responsible for the degradation of the organic bone matrix during bone remodeling. Recently, Cathepsin K was regarded as a potential target for therapeutic intervention of osteoporosis. H...

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Main Authors: Ulrike Sausbier, Christian Dullin, Jeannine Missbach-Guentner, Clement Kabagema, Katarina Flockerzie, Gerd Marten Kuscher, Walter Stuehmer, Winfried Neuhuber, Peter Ruth, Frauke Alves, Matthias Sausbier
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3114853?pdf=render

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http://europepmc.org/articles/PMC3114853?pdf=render

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