The STING-IFN-β-Dependent Axis Is Markedly Low in Patients with Relapsing-Remitting Multiple Sclerosis

The STING-IFN-β-Dependent Axis Is Markedly Low in Patients with Relapsing-Remitting Multiple Sclerosis

Cyclic GMP-AMP-synthase is a sensor of endogenous nucleic acids, which subsequently elicits a stimulator of interferon genes (STING)-dependent type I interferon (IFN) response defending us against viruses and other intracellular pathogens. This pathway can drive pathological inflammation, as documen...

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Bibliographic Details
Main Authors: Lars Masanneck, Susann Eichler, Anna Vogelsang, Melanie Korsen, Heinz Wiendl, Thomas Budde, Sven G. Meuth
Format: Article
Language:English
Published: MDPI AG 2020-12-01
Series:International Journal of Molecular Sciences
Subjects:
STING
cGAMP
interferon-beta
multiple sclerosis
RRMS
EAE
Online Access:https://www.mdpi.com/1422-0067/21/23/9249

Internet

https://www.mdpi.com/1422-0067/21/23/9249

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