TCRγδ(+)CD4(-)CD8(-) T cells suppress the CD8(+) T-cell response to hepatitis B virus peptides, and are associated with viral control in chronic hepatitis B.

TCRγδ(+)CD4(-)CD8(-) T cells suppress the CD8(+) T-cell response to hepatitis B virus peptides, and are associated with viral control in chronic hepatitis B.

The immune mechanisms underlying failure to achieve hepatitis B e antigen (HBeAg) seroconversion associated with viral control in chronic hepatitis B (CHB) remain unclear. Here we investigated the role of CD4(-)CD8(-) T (double-negative T; DNT) cells including TCRαβ(+) DNT (αβ DNT) and TCRγδ(+) DNT...

Full description

Bibliographic Details
Main Authors: Qintao Lai, Shiwu Ma, Jun Ge, Zuxiong Huang, Xuan Huang, Xiaotao Jiang, Yongyin Li, Mingxia Zhang, Xiaoyong Zhang, Jian Sun, William G H Abbott, Jinlin Hou
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3925121?pdf=render

Internet

http://europepmc.org/articles/PMC3925121?pdf=render

Similar Items