Integrin-Ligand Interactions in Inflammation, Cancer, and Metabolic Disease: Insights Into the Multifaceted Roles of an Emerging Ligand Irisin

Integrin-Ligand Interactions in Inflammation, Cancer, and Metabolic Disease: Insights Into the Multifaceted Roles of an Emerging Ligand Irisin

Integrins are transmembrane proteins that mediate cellular adhesion and migration to neighboring cells or the extracellular matrix, which is essential for cells to undertake diverse physiological and pathological pathways. For integrin activation and ligand binding, bidirectional signaling across th...

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Bibliographic Details
Main Authors: Eun Jeong Park, Phyoe Kyawe Myint, Atsushi Ito, Michael G. Appiah, Samuel Darkwah, Eiji Kawamoto, Motomu Shimaoka
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-10-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
integrin
ligand
irisin
inflammation
cancer
metabolic disease
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2020.588066/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2020.588066/full

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