Peroxisome deficiency but not the defect in ether lipid synthesis causes activation of the innate immune system and axonal loss in the central nervous system

Peroxisome deficiency but not the defect in ether lipid synthesis causes activation of the innate immune system and axonal loss in the central nervous system

<p>Abstract</p> <p>Background</p> <p>Mice with peroxisome deficiency in neural cells (<it>Nestin-Pex5</it><sup><it>−/−</it></sup><it>)</it> develop a neurodegenerative phenotype leading to motor and cognitive disabilities...

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Bibliographic Details
Main Authors: Bottelbergs Astrid, Verheijden Simon, Van Veldhoven Paul P, Just Wilhelm, Devos Rita, Baes Myriam
Format: Article
Language:English
Published: BMC 2012-03-01
Series:Journal of Neuroinflammation
Subjects:
Peroxisomes
Mouse models
Plasmalogens
Complement
Demyelination
Axonal degeneration
Inflammation
Macrophage
Online Access:http://www.jneuroinflammation.com/content/9/1/61

Internet

http://www.jneuroinflammation.com/content/9/1/61

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