The polyphenol/saponin-rich Rhus tripartita extract has an apoptotic effect on THP-1 cells through the PI3K/AKT/mTOR signaling pathway

The polyphenol/saponin-rich Rhus tripartita extract has an apoptotic effect on THP-1 cells through the PI3K/AKT/mTOR signaling pathway

Abstract Background Hyperactivation of mechanistic target of rapamycin (mTOR) signaling pathway is involved in the regulation of cellular growth, proliferation, and more in general, is a common phenomenon in most types of cancers. Thus, natural substances targeting this pathway can be of great thera...

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Bibliographic Details
Main Authors: Hajer Tlili, Anca Macovei, Daniela Buonocore, Manuela Lanzafame, Hanen Najjaa, Anita Lombardi, Andrea Pagano, Maurizia Dossena, Manuela Verri, Abdelkarim Ben Arfa, Mohamed Neffati, Enrico Doria
Format: Article
Language:English
Published: BMC 2021-05-01
Series:BMC Complementary Medicine and Therapies
Subjects:
Plant extracts
Medicinal plants
Rhus tripartita
mTOR pathway
Anticancer properties
Apoptosis
Online Access:https://doi.org/10.1186/s12906-021-03328-9

Internet

https://doi.org/10.1186/s12906-021-03328-9

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