Microencapsulation of <i>Salmonella</i>-Specific Bacteriophage Felix O1 Using Spray-Drying in a pH-Responsive Formulation and Direct Compression Tableting of Powders into a Solid Oral Dosage Form

Microencapsulation of <i>Salmonella</i>-Specific Bacteriophage Felix O1 Using Spray-Drying in a pH-Responsive Formulation and Direct Compression Tableting of Powders into a Solid Oral Dosage Form

The treatment of enteric bacterial infections using oral bacteriophage therapy can be challenging since the harsh acidic stomach environment renders phages inactive during transit through the gastrointestinal tract. Solid oral dosage forms allowing site-specific gastrointestinal delivery of high dos...

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Bibliographic Details
Main Authors: Gurinder K. Vinner, Zahra Rezaie-Yazdi, Miika Leppanen, Andrew G.F. Stapley, Mark C. Leaper, Danish J. Malik
Format: Article
Language:English
Published: MDPI AG 2019-03-01
Series:Pharmaceuticals
Subjects:
antibiotic resistance
bacteriophages
direct compression
microparticles
pH-responsive
spray drying
<i>salmonella</i>
tablets
Online Access:https://www.mdpi.com/1424-8247/12/1/43

Internet

https://www.mdpi.com/1424-8247/12/1/43

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