In silico and in vitro insights into tyrosinase inhibitors with a 2-thioxooxazoline-4-one template

In silico and in vitro insights into tyrosinase inhibitors with a 2-thioxooxazoline-4-one template

The β-phenyl-α,β-unsaturated carbonyl (PUSC) scaffold confers tyrosinase inhibitory activity, and in the present study, 16 (Z)-5-(substituted benzylidene)-3-phenyl-2-thioxooxazolidin-4-one analogues containing this scaffold were synthesized. Mushroom tyrosinase inhibitory activities were examined. C...

Full description

Bibliographic Details
Main Authors: Inkyu Choi, Yujin Park, Il Young Ryu, Hee Jin Jung, Sultan Ullah, Heejeong Choi, Chaeun Park, Dongwan Kang, Sanggwon Lee, Pusoon Chun, Hae Young Chung, Hyung Ryong Moon
Format: Article
Language:English
Published: Elsevier 2021-01-01
Series:Computational and Structural Biotechnology Journal
Subjects:
Tyrosinase
2-thioxooxazoline-4-one
Anti-melanogenesis
Kojic acid
Docking simulation
β-phenyl-α,β-unsaturated carbonyl scaffold
Online Access:http://www.sciencedirect.com/science/article/pii/S2001037020305262

Internet

http://www.sciencedirect.com/science/article/pii/S2001037020305262

Similar Items