Comparative Study of Two Processes to Improve the Bioavailability of an Active Pharmaceutical Ingredient: Kneading and Supercritical Technology

Comparative Study of Two Processes to Improve the Bioavailability of an Active Pharmaceutical Ingredient: Kneading and Supercritical Technology

Two processes have been developed for the enhancement of bioavailability of a poorly-soluble active substance, Eflucimibe by associating it with γ-CD (γ-cyclodextrin).In the first process (process a), Eflucimibe was added to an aqueous slurry of...

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Bibliographic Details
Main Authors: Jacques Fages, Elisabeth Rodier, Alain Chamayou, Michel Baron
Format: Article
Language:English
Published: Hosokawa Powder Technology Foundation 2014-03-01
Series:KONA Powder and Particle Journal
Subjects:
eflucimibe
cyclodextrin
kneading
supercritical co2
scale-up
bioavailability
Online Access:https://www.jstage.jst.go.jp/article/kona/25/0/25_2007019/_pdf/-char/en

Internet

https://www.jstage.jst.go.jp/article/kona/25/0/25_2007019/_pdf/-char/en

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