The Aspergillus fumigatus CrzA Transcription Factor Activates Chitin Synthase Gene Expression during the Caspofungin Paradoxical Effect

The Aspergillus fumigatus CrzA Transcription Factor Activates Chitin Synthase Gene Expression during the Caspofungin Paradoxical Effect

Aspergillus fumigatus is an opportunistic fungal pathogen that causes invasive aspergillosis (IA), a life-threatening disease in immunocompromised humans. The echinocandin caspofungin, adopted as a second-line therapy in combating IA, is a β-1,3-glucan synthase inhibitor, which, when used in high co...

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Main Authors: Laure Nicolas Annick Ries, Marina Campos Rocha, Patrícia Alves de Castro, Rafael Silva-Rocha, Roberto Nascimento Silva, Fernanda Zanolli Freitas, Leandro Josíé de Assis, Maria Cíéélia Bertolini, Iran Malavazi, Gustavo H. Goldman, J. Andrew Alspaugh
Format: Article
Language:English
Published: American Society for Microbiology 2017-06-01
Series:mBio
Online Access:http://mbio.asm.org/cgi/content/full/8/3/e00705-17

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http://mbio.asm.org/cgi/content/full/8/3/e00705-17

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