Attenuation of cell mechanosensitivity in colon cancer cells during in vitro metastasis.

Attenuation of cell mechanosensitivity in colon cancer cells during in vitro metastasis.

Human colon carcinoma (HCT-8) cells show a stable transition from low to high metastatic state when cultured on appropriately soft substrates (21 kPa). Initially epithelial (E) in nature, the HCT-8 cells become rounded (R) after seven days of culture on soft substrate. R cells show a number of metas...

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Bibliographic Details
Main Authors: Xin Tang, Qi Wen, Theresa B Kuhlenschmidt, Mark S Kuhlenschmidt, Paul A Janmey, Taher A Saif
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3511581?pdf=render

Internet

http://europepmc.org/articles/PMC3511581?pdf=render

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