RINCK-mediated monoubiquitination of cGAS promotes antiviral innate immune responses

RINCK-mediated monoubiquitination of cGAS promotes antiviral innate immune responses

Abstract Background As an important danger signal, the presence of DNA in cytoplasm triggers potent immune responses. Cyclic GMP-AMP synthase (cGAS) is a recently characterized key sensor for cytoplasmic DNA. The engagement of cGAS with DNA leads to the synthesis of a second messenger, cyclic GMP-AM...

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Bibliographic Details
Main Authors: Zhao-Shan Liu, Zi-Yu Zhang, Hong Cai, Ming Zhao, Jie Mao, Jiang Dai, Tian Xia, Xue-Min Zhang, Tao Li
Format: Article
Language:English
Published: BMC 2018-05-01
Series:Cell & Bioscience
Subjects:
RINCK
Monoubiquitination
cGAS
Innate immunity
Antiviral immunity
Online Access:http://link.springer.com/article/10.1186/s13578-018-0233-3

Internet

http://link.springer.com/article/10.1186/s13578-018-0233-3

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