Three Peptide Modulators of the Human Voltage-Gated Sodium Channel 1.7, an Important Analgesic Target, from the Venom of an Australian Tarantula

Three Peptide Modulators of the Human Voltage-Gated Sodium Channel 1.7, an Important Analgesic Target, from the Venom of an Australian Tarantula

Voltage-gated sodium (NaV) channels are responsible for propagating action potentials in excitable cells. NaV1.7 plays a crucial role in the human pain signalling pathway and it is an important therapeutic target for treatment of chronic pain. Numerous spider venom peptides have been shown to modula...

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Bibliographic Details
Main Authors: Chun Yuen Chow, Ben Cristofori-Armstrong, Eivind A. B. Undheim, Glenn F. King, Lachlan D. Rash
Format: Article
Language:English
Published: MDPI AG 2015-06-01
Series:Toxins
Subjects:
Phlogius sp.
spider venom
venom peptide
voltage-gated sodium channel
NaV1.7
two-electrode voltage clamp electrophysiology
ion channel
mass spectrometry
Online Access:http://www.mdpi.com/2072-6651/7/7/2494

Internet

http://www.mdpi.com/2072-6651/7/7/2494

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