Synthesis and Evaluation of Thiol-Conjugated Poloxamer and Its Pharmaceutical Applications

Synthesis and Evaluation of Thiol-Conjugated Poloxamer and Its Pharmaceutical Applications

The current study was designed to convert the poloxamer (PLX) into thiolated poloxamer (TPLX), followed by its physicochemical, biocompatibilities studies, and applications as a pharmaceutical excipient in the development of tacrolimus (TCM)-containing compressed tablets. Thiolation was accomplished...

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Bibliographic Details
Main Authors: Muhammad Zaman, Sadaf Saeed, Rabia Imtiaz Bajwa, Muhammad Shafeeq Ur Rahman, Saeed Ur Rahman, Muhammad Jamshaid, Muhammad F. Rasool, Abdul Majeed, Imran Imran, Faleh Alqahtani, Sultan Alshehri, Abdullah F. AlAsmari, Nemat Ali, Mohammed Alasmari
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:Pharmaceutics
Subjects:
poloxamer
thiourea
thiolation
mucoadhesion
drug release
in vivo analysis
Online Access:https://www.mdpi.com/1999-4923/13/5/693

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https://www.mdpi.com/1999-4923/13/5/693

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