Antigen-engaged B cells undergo chemotaxis toward the T zone and form motile conjugates with helper T cells.
Interactions between B and T cells are essential for most antibody responses, but the dynamics of these interactions are poorly understood. By two-photon microscopy of intact lymph nodes, we show that upon exposure to antigen, B cells migrate with directional preference toward the B-zone-T-zone boun...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2005-06-01
|
| Series: | PLoS Biology |
| Online Access: | http://europepmc.org/articles/PMC1088276?pdf=render |