Comparative Modeling and Molecular Dynamics Simulation of Substrate Binding in Human Fatty Acid Synthase: Enoyl Reductase and β-Ketoacyl Reductase Catalytic Domains

Comparative Modeling and Molecular Dynamics Simulation of Substrate Binding in Human Fatty Acid Synthase: Enoyl Reductase and β-Ketoacyl Reductase Catalytic Domains

Fatty acid synthase (FASN, EC 2.3.1.85), is a multi-enzyme dimer complex that plays a critical role in lipogenesis. This lipogenic enzyme has gained importance beyond its physiological role due to its implications in several clinical conditions-cancers, obesity, and diabetes. This has made FASN an a...

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Bibliographic Details
Main Authors: Arun John, Vetrivel Umashankar, Subramanian Krishnakumar, Perinkulam Ravi Deepa
Format: Article
Language:English
Published: Korea Genome Organization 2015-03-01
Series:Genomics & Informatics
Subjects:
β-ketoacyl reductase molecular dynamics simulation
comparative modeling
docking
enoyl reductase
fatty acid synthase
Online Access:http://genominfo.org/upload/pdf/gni-13-15.pdf

Internet

http://genominfo.org/upload/pdf/gni-13-15.pdf

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