S-Nitroso-N-acetyl-L-cysteine ethyl ester (SNACET) and N-acetyl-L-cysteine ethyl ester (NACET)–Cysteine-based drug candidates with unique pharmacological profiles for oral use as NO, H2S and GSH suppliers and as antioxidants: Results and overview

S-Nitroso-N-acetyl-L-cysteine ethyl ester (SNACET) and N-acetyl-L-cysteine ethyl ester (NACET)–Cysteine-based drug candidates with unique pharmacological profiles for oral use as NO, H2S and GSH suppliers and as antioxidants: Results and overview

S-Nitrosothiols or thionitrites with the general formula RSNO are formally composed of the nitrosyl cation (NO+) and a thiolate (RS−), the base of the corresponding acids RSH. The smallest S-nitrosothiol is HSNO and derives from hydrogen sulfide (HSH, H2S). The most common physiological S-nitrosothi...

Full description

Bibliographic Details
Main Authors: Dimitrios Tsikas, Kathrin S. Schwedhelm, Andrzej Surdacki, Daniela Giustarini, Ranieri Rossi, Lea Kukoc-Modun, George Kedia, Stefan Ückert
Format: Article
Language:English
Published: Elsevier 2018-02-01
Series:Journal of Pharmaceutical Analysis
Subjects:
CGMP
Nitric oxide
S-Nitrosothiols
Oxidative stress
Pharmaceuticals
Online Access:http://www.sciencedirect.com/science/article/pii/S2095177917301363

Internet

http://www.sciencedirect.com/science/article/pii/S2095177917301363

Similar Items