Carbon- versus sulphur-based zinc binding groups for carbonic anhydrase inhibitors?

Carbon- versus sulphur-based zinc binding groups for carbonic anhydrase inhibitors?

A set of compounds incorporating carbon-based zinc-binding groups (ZBGs), of the type PhX (X = COOH, CONH2, CONHNH2, CONHOH, CONHOMe), and the corresponding derivatives with sulphur(VI)-based ZBGs (X = SO3H, SO2NH2, SO2NHNH2, SO2NHOH, SO2NHOMe) were tested as inhibitors of all mammalian isoforms of...

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Bibliographic Details
Main Author: Claudiu T. Supuran
Format: Article
Language:English
Published: Taylor & Francis Group 2018-01-01
Series:Journal of Enzyme Inhibition and Medicinal Chemistry
Subjects:
Carbonic anhydrase
inhibitors
inhibition mechanism
zinc binder
anchoring to zinc-coordinated water
sulphonamide
hydroxamate
carboxylate
Online Access:http://dx.doi.org/10.1080/14756366.2018.1428572

Internet

http://dx.doi.org/10.1080/14756366.2018.1428572

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