Effects of interleukin‐6 receptor blockade on allergen‐induced airway responses in mild asthmatics

Effects of interleukin‐6 receptor blockade on allergen‐induced airway responses in mild asthmatics

Abstract Background Interleukin (IL)‐6 signalling has been implicated in allergic asthma by animal, genetic association and clinical studies. In this study, we tested the hypothesis that tocilizumab (TCZ), a human monoclonal antibody that blocks IL‐6 signalling, can prevent the development of allerg...

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Bibliographic Details
Main Authors: Joana A Revez, Lisa M Bain, Rick M Watson, Michelle Towers, Tina Collins, Kieran J Killian, Paul M O'Byrne, Gail M Gauvreau, John W Upham, Manuel AR Ferreira
Format: Article
Language:English
Published: Wiley 2019-01-01
Series:Clinical & Translational Immunology
Subjects:
actemra
allergy
GWAS
IL6
IL6R
rs2228145
Online Access:https://doi.org/10.1002/cti2.1044

Internet

https://doi.org/10.1002/cti2.1044

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