Kinetic competition during the transcription cycle results in stochastic RNA processing

Kinetic competition during the transcription cycle results in stochastic RNA processing

Synthesis of mRNA in eukaryotes involves the coordinated action of many enzymatic processes, including initiation, elongation, splicing, and cleavage. Kinetic competition between these processes has been proposed to determine RNA fate, yet such coupling has never been observed in vivo on single tran...

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Bibliographic Details
Main Authors: Antoine Coulon, Matthew L Ferguson, Valeria de Turris, Murali Palangat, Carson C Chow, Daniel R Larson
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2014-10-01
Series:eLife
Subjects:
transcription
RNA processing
splicing
single-molecule imaging
fluctuation analysis
Online Access:https://elifesciences.org/articles/03939

Internet

https://elifesciences.org/articles/03939

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