Kinetic, Thermodynamic, and Crystallographic Studies of 2-Triazolylthioacetamides as Verona Integron-Encoded Metallo-β-Lactamase 2 (VIM-2) Inhibitor

Kinetic, Thermodynamic, and Crystallographic Studies of 2-Triazolylthioacetamides as Verona Integron-Encoded Metallo-β-Lactamase 2 (VIM-2) Inhibitor

Inhibition of &#946;-lactamases presents a promising strategy to restore the &#946;-lactams antibacterial activity to resistant bacteria. In this work, we found that aromatic carboxyl substituted 2-triazolylthioacetamides <b>1a</b>&#8722;<b>j</b> inhibited VIM-2,...

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Bibliographic Details
Main Authors: Yang Xiang, Yue-Juan Zhang, Ying Ge, Yajun Zhou, Cheng Chen, Weixiao Yuan Wahlgren, Xiangshi Tan, Xi Chen, Ke-Wu Yang
Format: Article
Language:English
Published: MDPI AG 2020-01-01
Series:Biomolecules
Subjects:
antibiotic resistance
metallo-β-lactamase vim-2 inhibitor
2-triazolylthioacetamides
thermodynamics
crystallographic study
Online Access:https://www.mdpi.com/2218-273X/10/1/72

Internet

https://www.mdpi.com/2218-273X/10/1/72

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