Altered selenium status in Huntington's disease: Neuroprotection by selenite in the N171-82Q mouse model

Altered selenium status in Huntington's disease: Neuroprotection by selenite in the N171-82Q mouse model

Disruption of redox homeostasis is a prominent feature in the pathogenesis of Huntington's disease (HD). Selenium an essential element nutrient that modulates redox pathways and has been reported to provide protection against both acute neurotoxicity (e.g. methamphetamine) and chronic neurodege...

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Bibliographic Details
Main Authors: Zhen Lu, Eileen Marks, Jianfang Chen, Jenna Moline, Lorraine Barrows, Merl Raisbeck, Irene Volitakis, Robert A. Cherny, Vanita Chopra, Ashley I. Bush, Steven Hersch, Jonathan H. Fox
Format: Article
Language:English
Published: Elsevier 2014-11-01
Series:Neurobiology of Disease
Subjects:
Huntington's disease
Selenium
Selenoprotein
Diet
Neurodegeneration
Neuroprotection
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996114001867

Internet

http://www.sciencedirect.com/science/article/pii/S0969996114001867

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