New functional and structural insights from updated mutational databases for complement factor H, Factor I, membrane cofactor protein and C3
aHUS (atypical haemolytic uraemic syndrome), AMD (age-related macular degeneration) and other diseases are associated with defective AP (alternative pathway) regulation. CFH (complement factor H), CFI (complement factor I), MCP (membrane cofactor protein) and C3 exhibited the most disease-associate...
Main Authors: | , , , |
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Format: | Article |
Language: | English |
Published: |
Portland Press, Biochemical Society
2014-10-01
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Series: | Bioscience Reports |
Subjects: | |
Online Access: | http://www.bioscirep.org/bsr/034/e146/bsr034e146.htm |