Homer1a Attenuates Hydrogen Peroxide-Induced Oxidative Damage in HT-22 Cells through AMPK-Dependent Autophagy

Homer1a Attenuates Hydrogen Peroxide-Induced Oxidative Damage in HT-22 Cells through AMPK-Dependent Autophagy

Neuronal oxidative stress is involved in diverse neurological disorders. Homer1a, as an important member of the Homer family and localized at the postsynaptic density, is known to protect cells against oxidative injury. However, the exact neuroprotective mechanism of Homer1a has not been fully eluci...

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Bibliographic Details
Main Authors: Xiuquan Wu, Peng Luo, Wei Rao, Shuhui Dai, Lei Zhang, Wenke Ma, Jingnan Pu, Yang Yu, Jiu Wang, Zhou Fei
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-02-01
Series:Frontiers in Neuroscience
Subjects:
Homer1a
hydrogen peroxide
AMPK
autophagy
oxidative stress
mitochondrial dysfunction
Online Access:http://journal.frontiersin.org/article/10.3389/fnins.2018.00051/full

Internet

http://journal.frontiersin.org/article/10.3389/fnins.2018.00051/full

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