Optimizing recellularization of whole decellularized heart extracellular matrix.

Perfusion decellularization of cadaveric hearts removes cells and generates a cell-free extracellular matrix scaffold containing acellular vascular conduits, which are theoretically sufficient to perfuse and support tissue-engineered heart constructs. However, after transplantation, these acellular...

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Bibliographic Details
Main Authors: Matthew J Robertson, Jessica L Dries-Devlin, Stefan M Kren, Jana S Burchfield, Doris A Taylor
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3937369?pdf=render