TICRR Contributes to Tumorigenesis Through Accelerating DNA Replication in Cancers

TICRR Contributes to Tumorigenesis Through Accelerating DNA Replication in Cancers

DNA replication is precisely regulated in cells and its dysregulation can trigger tumorigenesis. Here we identified that the TOPBP1 interacting checkpoint and replication regulator (TICRR) mRNA level was universally and highly expressed in 15 solid cancer types. Depletion of TICRR significantly inhi...

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Bibliographic Details
Main Authors: Qin Yu, Shao-Yan Pu, Huan Wu, Xiao-Qiong Chen, Jian-Jun Jiang, Kang-Shuyun Gu, Yong-Han He, Qing-Peng Kong
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-06-01
Series:Frontiers in Oncology
Subjects:
TICRR
DNA replication
proliferation
p53 pathway
tumorigenesis
ATM/CHK2
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2019.00516/full

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https://www.frontiersin.org/article/10.3389/fonc.2019.00516/full

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