Structural Determinants of the APOBEC3G N-Terminal Domain for HIV-1 RNA Association

Structural Determinants of the APOBEC3G N-Terminal Domain for HIV-1 RNA Association

APOBEC3G (A3G) is a cellular protein that inhibits HIV-1 infection through virion incorporation. The interaction of the A3G N-terminal domain (NTD) with RNA is essential for A3G incorporation in the HIV-1 virion. The interaction between A3G-NTD and RNA is not completely understood. The A3G-NTD is al...

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Bibliographic Details
Main Authors: Hirofumi Fukuda, Songling Li, Luca Sardo, Jessica L. Smith, Kazuo Yamashita, Anamaria D. Sarca, Kotaro Shirakawa, Daron M. Standley, Akifumi Takaori-Kondo, Taisuke Izumi
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-05-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
APOBEC3G
RNA
DNA
HIV-1 Vif
Structural Model
Imaging
Online Access:https://www.frontiersin.org/article/10.3389/fcimb.2019.00129/full

Internet

https://www.frontiersin.org/article/10.3389/fcimb.2019.00129/full

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