Epigenetic Modifications of the Liver Tumor Cell Line HepG2 Increase Their Drug Metabolic Capacity

Epigenetic Modifications of the Liver Tumor Cell Line HepG2 Increase Their Drug Metabolic Capacity

Although human liver tumor cells have reduced metabolic functions as compared to primary human hepatocytes (PHH) they are widely used for pre-screening tests of drug metabolism and toxicity. The aim of the present study was to modify liver cancer cell lines in order to improve their drug-metabolizin...

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Bibliographic Details
Main Authors: Marc Ruoß, Georg Damm, Massoud Vosough, Lisa Ehret, Carl Grom-Baumgarten, Martin Petkov, Silvio Naddalin, Ruth Ladurner, Daniel Seehofer, Andreas Nussler, Sahar Sajadian
Format: Article
Language:English
Published: MDPI AG 2019-01-01
Series:International Journal of Molecular Sciences
Subjects:
tumor cells
epigenetic reprogramming
drug metabolism
hepatoma cell lines
primary human hepatocytes
Online Access:http://www.mdpi.com/1422-0067/20/2/347

Internet

http://www.mdpi.com/1422-0067/20/2/347

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