Multiple Myeloma Relapse Is Associated with Increased NFκB Pathway Activity and Upregulation of the Pro-Survival BCL-2 Protein BFL-1

Multiple Myeloma Relapse Is Associated with Increased NFκB Pathway Activity and Upregulation of the Pro-Survival BCL-2 Protein BFL-1

Multiple myeloma (MM) is a hematological malignancy that is still considered incurable due to the development of therapy resistance and subsequent relapse of disease. MM plasma cells (PC) use NFκB signaling to stimulate cell growth and disease progression, and for protection against therapy-induced...

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Bibliographic Details
Main Authors: Ingrid Spaan, Anja van de Stolpe, Reinier A. Raymakers, Victor Peperzak
Format: Article
Language:English
Published: MDPI AG 2021-09-01
Series:Cancers
Subjects:
relapsed/refractory multiple myeloma
NFκB signaling pathway
signal transduction pathway activity
pro-survival BCL-2
BFL-1
BCL2A1
Online Access:https://www.mdpi.com/2072-6694/13/18/4668

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https://www.mdpi.com/2072-6694/13/18/4668

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