Brain Metabolite, N-Acetylaspartate Is a Potent Protein Aggregation Inhibitor

Brain Metabolite, N-Acetylaspartate Is a Potent Protein Aggregation Inhibitor

Deposition of toxic protein inclusions is a common hallmark of many neurodegenerative disorders including Alzheimer's disease, Parkinson disease etc. N-acetylaspartate (NAA) is an important brain metabolite whose levels got altered under various neurodegenerative conditions. Indeed, NAA has bee...

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Bibliographic Details
Main Authors: Marina Warepam, Awdhesh Kumar Mishra, Gurumayum Suraj Sharma, Kritika Kumari, Snigdha Krishna, Mohd Sajjad Ahmad Khan, Hamidur Rahman, Laishram Rajendrakumar Singh
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Cellular Neuroscience
Subjects:
protein aggregation
light scattering
protein stability
protein denaturation
neurological disorders
Online Access:https://www.frontiersin.org/articles/10.3389/fncel.2021.617308/full

Internet

https://www.frontiersin.org/articles/10.3389/fncel.2021.617308/full

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