Compounds targeting YadC of uropathogenic Escherichia coli and its host receptor annexin A2 decrease bacterial colonization in bladder

Background: Uropathogenic Escherichia coli (UPEC) is the leading cause of urinary tract infections (UTIs), and fimbrial tip adhesins, play important roles in UPEC colonization. Few fimbrial tip adhesins and their receptors on host cells, which have the potential to be the therapeutic targets, have b...

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Bibliographic Details
Main Authors: Xiao Li, Geng Pei, Lisong Zhang, Yang Cao, Jingyu Wang, Lu Yu, Wei Dianjun, Shan Gao, Zhi-Song Zhang, Zhi Yao, Quan Wang
Format: Article
Language:English
Published: Elsevier 2019-12-01
Series:EBioMedicine
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396419307637