Increasing LFA-1 Expression Enhances Immune Synapse Architecture and T Cell Receptor Signaling in Jurkat E6.1 Cells

Increasing LFA-1 Expression Enhances Immune Synapse Architecture and T Cell Receptor Signaling in Jurkat E6.1 Cells

The Jurkat E6.1 clone has been extensively used as a powerful tool for the genetic and biochemical dissection of the TCR signaling pathway. More recently, these cells have been exploited in imaging studies to identify key players in immunological synapse (IS) assembly in superantigen-specific conjug...

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Bibliographic Details
Main Authors: Chiara Cassioli, Stefan Balint, Ewoud B. Compeer, James H. Felce, Alessandra Gamberucci, Chiara Della Bella, Suet Ling Felce, Jlenia Brunetti, Salvatore Valvo, Daniela Pende, Mario M. D’Elios, Lorenzo Moretta, Michael L. Dustin, Cosima T. Baldari
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-07-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
cSMAC
TCR signaling
supported lipid bilayer (SLB)
Jurkat cell
LFA-1
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.673446/full

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https://www.frontiersin.org/articles/10.3389/fcell.2021.673446/full

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