Sphingosine 1-phosphate-induced ICAM-1 expression via NADPH oxidase/ROS-dependent NF-kappaB cascade on human pulmonary alveolar epithelial cells

Sphingosine 1-phosphate-induced ICAM-1 expression via NADPH oxidase/ROS-dependent NF-kappaB cascade on human pulmonary alveolar epithelial cells

The intercellular adhesion molecule-1 (ICAM-1) expression is frequently correlated with the lung inflammation. A bioactive sphingolipid metabolite, sphingosine-1-phosphate (S1P), was involved in inflammation through the adhesion molecules induction, and then caused lung injury. However, the transduc...

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Bibliographic Details
Main Authors: Chin-Chung eLin, Chien-Chung eYang, Rou-Ling eCho, Chen-yu eWang, Li-Der eHsiao, Chuen-Mao eYang
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-03-01
Series:Frontiers in Pharmacology
Subjects:
Intercellular Adhesion Molecule-1
Transcription Factors
lung inflammation
Sphingosine-1-phosphate
Monocyte adhesion
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphar.2016.00080/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fphar.2016.00080/full

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