PLGA Microspheres with Alginate-Coated Large Pores for the Formulation of an Injectable Depot of Donepezil Hydrochloride

PLGA Microspheres with Alginate-Coated Large Pores for the Formulation of an Injectable Depot of Donepezil Hydrochloride

As the main symptom of Alzheimer’s disease-related dementia is memory loss, patient compliance for donepezil hydrochloride (donepezil), administered as once-daily oral formulations, is poor. Thus, we aimed to design poly(lactic-<i>co</i>-glycolic acid) (PLGA) microspheres (MS) with algin...

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Bibliographic Details
Main Authors: Dohyun Kim, Tae Hee Han, Seong-Chul Hong, Sun Jae Park, Yong Hak Lee, Hyeongmin Kim, Minwoo Park, Jaehwi Lee
Format: Article
Language:English
Published: MDPI AG 2020-04-01
Series:Pharmaceutics
Subjects:
donepezil depot
sustained release
porous microsphere
pore size
porosity
drug loading
Online Access:https://www.mdpi.com/1999-4923/12/4/311

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https://www.mdpi.com/1999-4923/12/4/311

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