Tyrosine-Protein Phosphatase Non-receptor Type 9 (PTPN9) Negatively Regulates the Paracrine Vasoprotective Activity of Bone-Marrow Derived Pro-angiogenic Cells: Impact on Vascular Degeneration in Oxygen-Induced Retinopathy

Tyrosine-Protein Phosphatase Non-receptor Type 9 (PTPN9) Negatively Regulates the Paracrine Vasoprotective Activity of Bone-Marrow Derived Pro-angiogenic Cells: Impact on Vascular Degeneration in Oxygen-Induced Retinopathy

Background and AimInsufficient post-ischemic neovascularization is an initial key step in the pathogenesis of Oxygen-Induced Retinopathy (OIR). During neovascularization, pro-angiogenic cells (PACs) are mobilized from the bone marrow and integrate into ischemic tissues to promote angiogenesis. Howev...

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Bibliographic Details
Main Authors: Michel Desjarlais, Pakiza Ruknudin, Maëlle Wirth, Isabelle Lahaie, Rabah Dabouz, José Carlos Rivera, Tiffany Habelrih, Samy Omri, Pierre Hardy, Alain Rivard, Sylvain Chemtob
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
pro-angiogenic cell
vascular degeneration
tyrosine-protein phosphatase non-receptor type 9
oxygen-induced retinopathy
angiogenesis
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.679906/full

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https://www.frontiersin.org/articles/10.3389/fcell.2021.679906/full

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